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Phenotypes Associated with This Genotype
Genotype
MGI:3717173
Allelic
Composition
Prex1tm1Hcew/Prex1tm1Hcew
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prex1tm1Hcew mutation (0 available); any Prex1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when stimulated with fMLP, neutrophil migration speed is mildly reduced
• mild neutrophilia with 61% more peripheral neutrophils compared to wild-type mice
• in an aseptic peritonitis model, thioglycollate-stimulated recruitment of neutrophil is 50% of that in wild-type mice

behavior/neurological
N
• mice exhibit normal motor coordination and balance on the rotarod and locomotor activity in an open field test and do not exhibit anxiety-like behavior
• in a modified 4-trial social memory assay, mutants show no habituation to the stimulus mouse or dishabituation to the novel mouse, indicating impaired social memory
• mutants show a smaller reduction in freezing time during the extinction phase of contextual fear, indicating behavioral inflexibility
• however, mutants do not differ from wild-type mice in the delayed nonmatch to place T-maze task
• in a reversal learning tasking using the Morris water maze, mutants show an impairment in learning the new platform location and spend equivalent amounts of time in the new target and opposite quadrants
• mutants spend more time grooming than wild-type mice
• however, mutants show normal jumping and digging behaviors
• mutants show normal sociability in the initial trial of the 3-chamber social interaction assay, however in the subsequent social novelty trial, mutants spend almost identical amounts of time interacting with stranger 1 and with stranger 2 instead of showing a preference for the novel (stranger2) mouse as seen in wild-type mice
• treatment of mice with D-serine significantly improves social recognition
• -however, mice exhibit a normal interest in novelty in the novel-object recognition assay and normal social novelty recognition between a stranger mouse and a familiar cohoused mouse
• mutant pups emit fewer ultrasonic calls than wild-type mice

nervous system
N
• mutants exhibit normal prepulse inhibition and normal quantity and distribution of cortical and hippocampal neurons and complexity of the dendrites in the neurons of the CA1 region
• NMDAR-dependent LTD is impaired in the cerebellum but not in the primary visual cortex of mutants
• treatment of mice with D-serine fully rescues the NMDAR-dependent LTD impairment
• however, AMPAR-mediated basal synaptic transmission and presynaptic transmitter release are normal, metabotropic glutamate receptor-dependent LTD is normal, and long-term potentiation (LTP) and depolarization are intact

liver/biliary system

growth/size/body
• at 10 weeks mice weigh 14% less than wild-type mice and remain smaller (J:102214)
• mutants weigh slightly less than wild-type mice at 12 and 16 weeks of age (J:228203)

hematopoietic system
• when stimulated with fMLP, neutrophil migration speed is mildly reduced
• mild neutrophilia with 61% more peripheral neutrophils compared to wild-type mice
• in an aseptic peritonitis model, thioglycollate-stimulated recruitment of neutrophil is 50% of that in wild-type mice

cellular
• when stimulated with fMLP, neutrophil migration speed is mildly reduced

taste/olfaction
N
• mice exhibit normal odor recognition


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory