Phenotypes Associated with This Genotype

Genotype
MGI:3716965

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Trp53^tm2Tyj/Trp53⁺
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:103407 , J:191425 )

• following cre-adenovirus treatment, all mice develop primary lung tumors that are similar to those found in Kras^tm4Tyj Trp53^tm1Brn heterozygotes (J:103407)

• following cre-adenovirus treatment, tumors occupy 27% of lung space (J:103407)

• mice treated with intratracheal delivery of cre-expressing adenovirus develop lung cancer (J:191425)

• mice infected with higher doses of cre expressing adenovirus present with clinical signs of lung cancer by 15 weeks of treatment while lower dosed animals show signs of disease around 37 weeks (J:191425)

• a subset of tumors from mice treated with intratracheal delivery of cre-expressing adenovirus show loss of heterozygosity of Trp53 (J:191425)

• treatment of mice treated with intratracheal delivery of cre-expressing adenovirus with an miR-34 expressing lentilvirus almost completely abrogates tumor formation (J:191425)

• treatment of mice that have already formed lung tumors following intratracheal delivery of cre-expressing adenovirus with an miR-34 expressing lentilvirus prevents further progression of tumors (J:191425)

increased lung non-small cell carcinoma incidence ( J:191425 )

• mice treated with intratracheal delivery of cre-expressing adenovirus show evidence that high-grade adenocarcinomas acquire metastatic characteristics of non-small cell lung cancer

increased lung adenocarcinoma incidence ( J:191425 )

• tumors of mice treated with intratracheal delivery of cre-expressing adenovirus are adenocarcinomas and some evidence that high-grade adenocarcinomas acquire metastatic characteristics

immune system

lung inflammation ( J:191425 )

• mice treated with intratracheal delivery of cre-expressing adenovirus exhibit large lungs filled with tumors and inflammation

• the inflammation that develops in the lungs of mice treated with intratracheal delivery of cre-expressing adenovirus occurs after initial nodules develop

behavior/neurological

hunched posture ( J:191425 )

• mice treated with intratracheal delivery of cre-expressing adenovirus develop a hunched posture in the most severe cases

growth/size/body

weight loss ( J:191425 )

• mice treated with intratracheal delivery of cre-expressing adenovirus exhibit a decline in weight

respiratory system

lung inflammation ( J:191425 )

• mice treated with intratracheal delivery of cre-expressing adenovirus exhibit large lungs filled with tumors and inflammation

• the inflammation that develops in the lungs of mice treated with intratracheal delivery of cre-expressing adenovirus occurs after initial nodules develop

increased lung tumor incidence ( J:103407 , J:191425 )

• following cre-adenovirus treatment, all mice develop primary lung tumors that are similar to those found in Kras^tm4Tyj Trp53^tm1Brn heterozygotes (J:103407)

• following cre-adenovirus treatment, tumors occupy 27% of lung space (J:103407)

• mice treated with intratracheal delivery of cre-expressing adenovirus develop lung cancer (J:191425)

• mice infected with higher doses of cre expressing adenovirus present with clinical signs of lung cancer by 15 weeks of treatment while lower dosed animals show signs of disease around 37 weeks (J:191425)

• a subset of tumors from mice treated with intratracheal delivery of cre-expressing adenovirus show loss of heterozygosity of Trp53 (J:191425)

• treatment of mice treated with intratracheal delivery of cre-expressing adenovirus with an miR-34 expressing lentilvirus almost completely abrogates tumor formation (J:191425)

• treatment of mice that have already formed lung tumors following intratracheal delivery of cre-expressing adenovirus with an miR-34 expressing lentilvirus prevents further progression of tumors (J:191425)

increased lung non-small cell carcinoma incidence ( J:191425 )

• mice treated with intratracheal delivery of cre-expressing adenovirus show evidence that high-grade adenocarcinomas acquire metastatic characteristics of non-small cell lung cancer

increased lung adenocarcinoma incidence ( J:191425 )

• tumors of mice treated with intratracheal delivery of cre-expressing adenovirus are adenocarcinomas and some evidence that high-grade adenocarcinomas acquire metastatic characteristics

respiratory distress ( J:191425 )

• mice treated with intratracheal delivery of cre-expressing adenovirus exhibit labored breathing

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:191425