Phenotypes Associated with This Genotype

Genotype
MGI:3716855

• Allelic Composition: Kras^tm1Bbd/Kras⁺; Mapk14^tm1Nbr/Mapk14^tm2Nbr; Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:122397 )

• mice die before week 32 due to increased lung cancer progression

respiratory system

enlarged lung ( J:122397 )

• 20 weeks after treatment, lungs are increased in size

increased lung tumor incidence ( J:122397 )

• 2 weeks after 5-hydroxytamoxifen treatment, small tumors are found in the lungs

• 20 weeks after treatment, lungs are oversized with 2-3 times as many tumors, many often >2mm in diameter, while lungs of Kras, Mapk14 heterozygotes have normal lungs with fewer, smaller tumors; tumors in Mapk14 homozygotes are more poorly differentiated and have higher mitotic indices

• at 26 weeks, total tumor number is slightly higher than in controls with much higher numbers of tumors larger than 2 mm in diameter and a higher ratio of lung mass to total mass

increased lung adenoma incidence ( J:122397 )

• tumors are detected 2 weeks after 5-hydroxytamoxifen treatment and after 4 weeks, clear signs of adenomas are present in most lungs compared to only a few small adenomas in lungs of treated Kras, Mapk14^tm2Nbr/+ control mice

increased lung adenocarcinoma incidence ( J:122397 )

• adenocarcinomas are detected at 15 weeks but not in controls

abnormal lung development ( J:122397 )

• lung differentiation is abnormal with increased SP-C-positive cells

neoplasm

abnormal tumor incidence ( J:122397 )

• mice also have tumors in the thymus and organs such as kidney and liver by 24 weeks after treatment whereas controls only have tumors in lungs and thymus

increased lung tumor incidence ( J:122397 )

• 2 weeks after 5-hydroxytamoxifen treatment, small tumors are found in the lungs

• 20 weeks after treatment, lungs are oversized with 2-3 times as many tumors, many often >2mm in diameter, while lungs of Kras, Mapk14 heterozygotes have normal lungs with fewer, smaller tumors; tumors in Mapk14 homozygotes are more poorly differentiated and have higher mitotic indices

• at 26 weeks, total tumor number is slightly higher than in controls with much higher numbers of tumors larger than 2 mm in diameter and a higher ratio of lung mass to total mass

increased lung adenoma incidence ( J:122397 )

• tumors are detected 2 weeks after 5-hydroxytamoxifen treatment and after 4 weeks, clear signs of adenomas are present in most lungs compared to only a few small adenomas in lungs of treated Kras, Mapk14^tm2Nbr/+ control mice

increased lung adenocarcinoma incidence ( J:122397 )

• adenocarcinomas are detected at 15 weeks but not in controls

growth/size/body

enlarged lung ( J:122397 )

• 20 weeks after treatment, lungs are increased in size