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Phenotypes Associated with This Genotype
Genotype
MGI:3716844
Allelic
Composition
Apoeshl/Apoeshl
Genetic
Background
involves: C3H/He * KOR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Xanthoma of Apoeshl/Apoeshl mice

mortality/aging
• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism
• cholesterol levels are high prior to weaning and decrease
• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back
• at 3 months, lesions are apparent at periocular and chest regions
• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system
• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument
• associated with xanthoma lesions on chest

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein E; APOE 107741 J:54051


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory