Apoe^shl
Spontaneous Allele Detail

Summary

• Symbol: Apoe^shl
• Name: apolipoprotein E; spontaneous hyperlipidemia
• MGI ID: MGI:3574899
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^shl page

Xanthoma of Apoe^shl/Apoe^shl mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: KOR

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Undefined
• Mutation details: This mutation was shown to be an allele of Apoe by complementation testing against Apoe^tm1Unc and by observation of altered restriction fragment sizes upon Southern blot analysis using a partial Apoe cDNA probe. (J:54051)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 145 strains or lines available

Notes

Northern blot analysis of liver RNA and immunoblot analysis of plasma from homozygous mice demonstrated lack of expression of Apoe RNA and protein. The phenotype is generally similar to that of targeted Apoe mutations on the same diet. Mice of the original mutant strain (SHL) exhibit more severe xanthoma and hypercholesterolemia, and at an earlier age, than do homozygous mice congenic for the mutation on three standard laboratory inbred-strain backgrounds. In contrast, atherosclerotic lesions of the aortae of congenic mutants are more extensive than those of SHL mice. SHL mice seldom survive past 12 months of age.

References

• Original: J:54051 Matsushima Y, et al., Spontaneously hyperlipidemic (SHL) mice: Japanese wild mice with apolipoprotein E deficiency. Mamm Genome. 1999 Apr;10(4):352-7
• All: 16 reference(s)