Phenotypes Associated with This Genotype

Genotype
MGI:3716839

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: KOR-Apoe^shl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:75488 )

• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoe^shl, C3.KOR-Apoe^shl, C.KOR-Apoe^shl, and B6.KOR-Apoe^shl

• Background Sensitivity: newborns have extremely high cholesterol levels that decrease exponentially towards weaning on a KOR background

xanthoma ( J:75488 )

• Background Sensitivity: lesions are severe on a KOR background

cardiovascular system

increased susceptibility to atherosclerosis ( J:75488 )

• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoe^shl, C.KOR-Apoe^shl, C3.KOR-Apoe^shl, KOR-Apoe^shl

behavior/neurological

abnormal nursing ( J:75488 )

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