Phenotypes Associated with This Genotype

Genotype
MGI:3716591

• Allelic Composition: Usp8^tm1.1Kpk/Usp8^tm1.1Kpk; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:122732 )

• 4-6 days after induction of cre expression with pI:pC (poly(I:C)), mice become moribund and die

liver/biliary system

increased hepatocyte apoptosis ( J:122732 )

• 4 days after pI:pC administration, apoptotic hepatocytes are observed around the central vein; extended sinoids and apoptotic figures are seen

• on day 6, apoptotic figures and ubiquitous degeneration of hepatocytes over all zones of hepatic lobules are observed

abnormal hepatocyte morphology ( J:122732 )

• 4 days after treatment, immature hepatocytes around the portal field display swelling and are vacuolized

hepatic necrosis ( J:122732 )

• on day 7 after treatment, lytic necrosis is observed over all hepatic lobules

jaundice ( J:122732 )

• upon induction of cre expression with pI:pC treatment, mice develop severe jaundice

liver failure ( J:122732 )

• treated mice show severe liver injury within 4-6 days of pI:pC treatment manifested by high levels of hepatocyte apoptosis and tissue necrosis

homeostasis/metabolism

increased circulating bilirubin level ( J:122732 )

• after cre induction, treated mice exhibit hyperbilirubinemia

cellular

increased hepatocyte apoptosis ( J:122732 )

• 4 days after pI:pC administration, apoptotic hepatocytes are observed around the central vein; extended sinoids and apoptotic figures are seen

• on day 6, apoptotic figures and ubiquitous degeneration of hepatocytes over all zones of hepatic lobules are observed