Phenotypes Associated with This Genotype

Genotype
MGI:3716394

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(SFTPC-rtTA)5Jaw/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:119477 )

• death in the early postnatal period

respiratory system

abnormal branching involved in lung morphogenesis ( J:119477 )

• with doxycycline treatment beginning at E6.5, a dramatic lung branching defect is observed

• at E16.5, lungs show even more severe defects than in Kras:Meox2-cre embryos, with large epithelial-lined pouches in place of finely branched network of airways seen in wild-type

• branching defect persists through late gestation leading to early postnatal lethality

abnormal lung epithelium morphology ( J:119477 )

• branching defect originates in epithelium rather than mesenchyme

abnormal bronchus epithelium morphology ( J:119477 )

• markers of ciliated and Clara cells in the bronchi are significantly reduced at E18.5 compared to controls, indicating block in differentiation of lung epithelium