Phenotypes Associated with This Genotype

Genotype
MGI:3716103

• Allelic Composition: Isl1^tm1(cre)Tmj/Isl1⁺; Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased muscle spindle number ( J:100886 )

• mice have 25% of the wild-type number of muscle spindles

abnormal sensory neuron morphology ( J:100886 )

• while sensory axons reach the skin only rudimentary sensory axon branching is established within the skin

abnormal sensory neuron innervation pattern ( J:100886 )

• sensory afferents fail to invade the spinal cord and are found in an extreme lateral position at the dorsal root entry zone

• sensory afferents are bifurcated at the entry point

• sensory afferent fibers fail to approach the midline at the distal segments and continue to occupy an extreme lateral position

abnormal dorsal root ganglion morphology ( J:100886 )

• unlike wild-type cells, dorsal root ganglia neurons survive in culture without the addition of neurotrophic agents

• whole dorsal root ganglia require neurotrophin-3 for survival

muscle

decreased muscle spindle number ( J:100886 )

• mice have 25% of the wild-type number of muscle spindles