Phenotypes Associated with This Genotype

Genotype
MGI:3715933

• Allelic Composition: Dntt^tm1Tok/Dntt^tm1Tok
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal lymphocyte cell number ( J:61801 )

• at E15.5-18.5, embryos have ~30-50% lower numbers of alphabeta- gammadelta+ and Vgamma3+ Thy-1.2+ thymocytes relative to controls

• populations of Vgamma3+ HSA^high Vgamma3+ HAS^low cells are reduced, also

abnormal T cell morphology ( J:61801 )

• occurrence of N regions (addition of nucleotides at V-(D)-J junctions) in T-cell receptor genes is lower in homozygotes, thus reducing potential rearrangements of TCRs in T cell generation

decreased gamma-delta T cell number ( J:61801 )

• decrease in gammadelta+ T cells relative to wild-type

immune system

abnormal lymphocyte cell number ( J:61801 )

• at E15.5-18.5, embryos have ~30-50% lower numbers of alphabeta- gammadelta+ and Vgamma3+ Thy-1.2+ thymocytes relative to controls

• populations of Vgamma3+ HSA^high Vgamma3+ HAS^low cells are reduced, also

abnormal T cell morphology ( J:61801 )

• occurrence of N regions (addition of nucleotides at V-(D)-J junctions) in T-cell receptor genes is lower in homozygotes, thus reducing potential rearrangements of TCRs in T cell generation

decreased gamma-delta T cell number ( J:61801 )

• decrease in gammadelta+ T cells relative to wild-type