Phenotypes for Del(2Hoxd10-Hoxd13)7Ddu Del(6Hoxa)1Ddu Hoxa Tg(Prrx1-cre)1Cjt MGI:3715858 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Del(2Hoxd10-Hoxd13)7Ddu/Del(2Hoxd10-Hoxd13)7Ddu Hoxa^tm1Ddu/Del(6Hoxa)1Ddu Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd10-Hoxd13)7Ddu mutation (0 available); any Del(2Hoxd10-Hoxd13)7Ddu mutation (0 available)
Del(6Hoxa)1Ddu mutation (0 available); any Del(6Hoxa)1Ddu mutation (0 available)
Hoxa^tm1Ddu mutation (0 available); any Hoxa mutation (0 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal forelimb zeugopod morphology ( J:114566 )

• no genuine forearm in newborn mice

absent radius ( J:114566 )

absent ulna ( J:114566 )

abnormal limb development ( J:114566 )

• abnormal segmented cartilaginous condensation is present, instead of digits, radii, or ulnae

abnormal digit development ( J:114566 )

• no genuine digits form on forelimb in newborn mice

skeleton

absent radius ( J:114566 )

absent ulna ( J:114566 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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