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Phenotypes Associated with This Genotype
Genotype
MGI:3715447
Allelic
Composition		 Mdm2tm1Bay/Mdm2tm1Mep
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Bay mutation (1 available); any Mdm2 mutation (53 available)
Mdm2tm1Mep mutation (1 available); any Mdm2 mutation (53 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:81065 )
N
• thymus is same size as in wild-type mice; thymocytes show wild-type levels of apoptosis and B cells show wild-type levels also
• number of B220+ B cells in bone marrow is similar to wild-type mice
abnormal bone marrow cell morphology/development ( J:81065 )
• 1.9-fold increase in number of apoptotice B cells relative to wild-type bone marrow

digestive/alimentary system
abnormal small intestine morphology ( J:81065 )
• 17-fold increase in spontaneous apoptosis, occurring mainly in the crypts rather than villi

mortality/aging
decreased mortality induced by ionizing radiation ( J:81065 )
• 100% of animals survive at least 35 days after treatment

homeostasis/metabolism
decreased mortality induced by ionizing radiation ( J:81065 )
• 100% of animals survive at least 35 days after treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory