Phenotypes Associated with This Genotype

Genotype
MGI:3715212

• Allelic Composition: Itgb1^tm1Efu/Itgb1^tm1Efu; Tg(Cryaa-cre)10Mlr/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens epithelium morphology ( J:122566 )

• at E16.5, mild lens epithelial elongation is observed

• at birth, lens epithelium is missing and remaining epithelial cells are abnormally elongated

• at birth, epithelial cells in the lens are lost by apoptosis

abnormal lens fiber morphology ( J:122566 )

• at birth, lens fibers are highly vacuolated and disintegrating

aphakia ( J:122566 )

• adult mice have little to no lens material

microphthalmia ( J:122566 )

• microphthalmia in adults

• however, mice are born with normal sized eyes