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Phenotypes Associated with This Genotype
Genotype
MGI:3714968
Allelic
Composition
Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1tm1.3Dgt mutation (1 available); any Spi1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• leukemic mice livers weigh 3.0 to 7.2g compared to 1 to 1.5g in wild-type mice
• due to expansion of myeloid cells
• spleen is 1.5 to 2 times bigger than in wild-type mice
• leukemic mice spleens weigh 600 to 1,600mg compared to 80 to 150mg in wild-type mice
• due to expansion of myeloid cells

endocrine/exocrine glands
• T cell lymphomas accompany myeloid leukemia and was the dominant disease in 2 mice

mortality/aging
• mice are moribund or die by 3 to 8 months from fatal, aggressive neoplastic disease

neoplasm
• T cell lymphomas accompany myeloid leukemia and was the dominant disease in 2 mice
• mice develop fatal, aggressive neoplastic disease similar to AML (acute myelogenous leukemia)

immune system
• at 2 to 3 months of age, neutrophil numbers are increased relative to wild-type mice
• mice have fewer B lymphoid cells
• abnormal architecture due to expansion of myeloid cells
• spleen is 1.5 to 2 times bigger than in wild-type mice
• leukemic mice spleens weigh 600 to 1,600mg compared to 80 to 150mg in wild-type mice
• due to expansion of myeloid cells

liver/biliary system
• abnormal architecture due to expansion of myeloid cells
• leukemic mice livers weigh 3.0 to 7.2g compared to 1 to 1.5g in wild-type mice
• due to expansion of myeloid cells

cellular
• trisomy 15 is common in mice with T cell lymphomas

hematopoietic system
• moribund mice accumulate immature myeloid cells in bone marrow and spleen
• mice have fewer erythroid cells
• at 2 to 3 months of age, neutrophil numbers are increased relative to wild-type mice
• mice have fewer B lymphoid cells
• abnormal architecture due to expansion of myeloid cells
• spleen is 1.5 to 2 times bigger than in wild-type mice
• leukemic mice spleens weigh 600 to 1,600mg compared to 80 to 150mg in wild-type mice
• due to expansion of myeloid cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:90331


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory