Phenotypes Associated with This Genotype

Genotype
MGI:3714649

• Allelic Composition: Tapbp^tm1Luc/Tapbp^tm1Luc; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal negative T cell selection ( J:64177 )

• double-negative thymocytes are allowed to progress to double- and single-positive stages, indicating defective negative selection

abnormal positive T cell selection ( J:64177 )

• also observed to be defective

abnormal CD4-positive, alpha beta T cell morphology ( J:64177 )

• female mice have increased numbers of CD4+CD8- T cells not expressing the transgene in the lymph node and thymus

• male mutants also show skewing toward CD4+ lineage

abnormal CD8-positive, alpha beta T cell morphology ( J:64177 )

• female mice have substantially reduced numbers of CD4-CD8+ H-Y TCR+ cells in thymus and periphery compared to controls

immune system

immune system phenotype ( J:64177 )

N • male mutants have normal-sized thymuses, whereas Tapbp-sufficient, transgenic males have a small thymus

abnormal negative T cell selection ( J:64177 )

• double-negative thymocytes are allowed to progress to double- and single-positive stages, indicating defective negative selection

abnormal positive T cell selection ( J:64177 )

• also observed to be defective

abnormal CD4-positive, alpha beta T cell morphology ( J:64177 )

• female mice have increased numbers of CD4+CD8- T cells not expressing the transgene in the lymph node and thymus

• male mutants also show skewing toward CD4+ lineage

abnormal CD8-positive, alpha beta T cell morphology ( J:64177 )

• female mice have substantially reduced numbers of CD4-CD8+ H-Y TCR+ cells in thymus and periphery compared to controls