Phenotypes Associated with This Genotype

Genotype
MGI:3714601

• Allelic Composition: Del(4D4Mit190-D4Mit51)2Aam/+
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitosis ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos have fewer cells in G2/M (11.9% compared to 16.9% in wild-type cells)

increased fibroblast proliferation ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos have enhanced proliferative potential compared to wild-type cells with fewer cells in G2/M (11.9% compared to 16.9% in wild-type cells)

delayed cellular replicative senescence ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos exhibit delayed senescence, are sensitive to immortalization and form foci instead of being limited to a monolayer

neoplasm

increased lymphoma incidence ( J:121726 )

• 2 of 4 adult mice examined develop lymphomas

increased squamous cell carcinoma incidence ( J:121726 )

• in adults, squamous cell carcinoma occurred in one animal

digestive/alimentary system

esophageal epithelium hyperplasia ( J:121726 )

• in adults, gastroesophageal epithelial hyperplasia occurs

hematopoietic system

spleen hyperplasia ( J:121726 )

• in adults

immune system

spleen hyperplasia ( J:121726 )

• in adults

renal/urinary system

abnormal renal/urinary system morphology ( J:121726 )

• in adults, genitourinary hyperplasia occurs

reproductive system

uterus hyperplasia ( J:121726 )

♀ • in adults, uterine hyperplasia occurs

growth/size/body

spleen hyperplasia ( J:121726 )

• in adults