Phenotypes Associated with This Genotype

Genotype
MGI:3714354

• Allelic Composition: Ctla4^tm1Shr/Ctla4^tm1Shr; Tg(DO11.10)10Dlo/0
• Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:57090 )

• mild splenomegaly observed in 6-8 week-old mice

abnormal T cell physiology ( J:57090 )

• 3 to 4 days after priming with ovalbumin peptide and antigen-presenting cells, T cells produce Il-4, whereas Ctla4-sufficient, Tg(DO11.10)10Dlo cells do not

• T cells produce Th2 cytokines (Il-4, Il-5, and Il-10) upon restimulation with antigen and APCs, whereas Tg(DO11.10)10Dlo cells produce the Th1 cytokine interferon gamma; Th2 bias is seen over a range of peptide concentration during primary stimulation

increased T cell proliferation ( J:57090 )

• in recall responses, T cells proliferate more than wild-type Tg(DO11.10)10Dlo cells

immune system

enlarged spleen ( J:57090 )

• mild splenomegaly observed in 6-8 week-old mice

abnormal T cell physiology ( J:57090 )

• 3 to 4 days after priming with ovalbumin peptide and antigen-presenting cells, T cells produce Il-4, whereas Ctla4-sufficient, Tg(DO11.10)10Dlo cells do not

• T cells produce Th2 cytokines (Il-4, Il-5, and Il-10) upon restimulation with antigen and APCs, whereas Tg(DO11.10)10Dlo cells produce the Th1 cytokine interferon gamma; Th2 bias is seen over a range of peptide concentration during primary stimulation

increased T cell proliferation ( J:57090 )

• in recall responses, T cells proliferate more than wild-type Tg(DO11.10)10Dlo cells

enlarged lymph nodes ( J:57090 )

• mild lymphadenopathy observed in 6-8 week-old mice

growth/size/body

enlarged spleen ( J:57090 )

• mild splenomegaly observed in 6-8 week-old mice

cellular

increased T cell proliferation ( J:57090 )

• in recall responses, T cells proliferate more than wild-type Tg(DO11.10)10Dlo cells