Phenotypes for Notch1 Tg(Pax2-cre)1Akg MGI:3713803 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Notch1^tm1Con/Notch1^tm1Grid Tg(Pax2-cre)1Akg/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (116 available)
Notch1^tm1Grid mutation (0 available); any Notch1 mutation (116 available)
Tg(Pax2-cre)1Akg mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119907 )

• embryos are normal at E12.5, but die at E13.5

renal/urinary system

renal/urinary system phenotype ( J:119907 )

N	• metanephroi appear normal morphologically and histologically when cultured at E12.5

cardiovascular system

abnormal vascular development ( J:119907 )

internal hemorrhage ( J:119907 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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