Phenotypes Associated with This Genotype

Genotype
MGI:3713713

• Allelic Composition: Plin1^tm1Asg/Plin1^tm1Asg; Tg(Fabp4-Plin*)1Asg/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased brown adipose tissue amount ( J:121641 )

• interscapular BAT depots are similar in weight to wild-type mice (0.16 g vs 0.15 g in controls)

• interscapular BAT depots are slightly larger, contain larger lipid droplets, and have 67% less triacylglycerol content than wild-type

abnormal white adipose tissue mass ( J:121641 )

• white adipose tissue depots are smaller than those in controls, but larger than those in Plin-null mice

abnormal adipose tissue physiology ( J:113735 )

• glycerol release in response to norepinephrine treatment is blunted in null MEFs expressing the transgene relative to wild-type MEFs

abnormal brown adipose tissue physiology ( J:121641 )

• interscapular BAT thermal profile is ~70% reduced compared to wild-type; temperature increases >1 degree Celsius

• in brown adipocytes, norepinephrine-induced lipolysis is abrogated relative to wild-type; basal glycerol and fatty acid release are lower than in wild-type or Plin-null adipocytes

• norepinephrine does not stimulate release as it does in wild-type adipocytes

homeostasis/metabolism

abnormal body temperature homeostasis ( J:121641 )

• in response to 30 minutes of norepinephrine infusion, thermal response is significantly blunted compared to wild-type or Plin-null mice; core temperature does not increase significantly with norepineprine infusion

impaired lipolysis ( J:113735 )