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Phenotypes Associated with This Genotype
Genotype
MGI:3713581
Allelic
Composition		 Braftm1Sva/Braftm1.1Sva
Raf1tm1Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1.1Sva mutation (0 available); any Braf mutation (58 available)
Braftm1Sva mutation (1 available); any Braf mutation (58 available)
Raf1tm1Bacc mutation (0 available); any Raf1 mutation (114 available)
Raf1tm2Bacc mutation (0 available); any Raf1 mutation (114 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:121660 )
• no double conditional embryos are found live at E14-15, but can be isolated at E13

nervous system
abnormal axon extension ( J:121660 )
• DRG neurons cultured with NGF for 5 days show impaired axon outgrowth
abnormal innervation ( J:121660 )
• sensory nerve trunks form normally, but distal arborization is reduced compared to controls
abnormal dorsal root ganglion morphology ( J:121660 )
• at E13, Ret levels in DRGs are reduced

cellular
abnormal axon extension ( J:121660 )
• DRG neurons cultured with NGF for 5 days show impaired axon outgrowth

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory