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Phenotypes Associated with This Genotype
Genotype
MGI:3713555
Allelic
Composition
Braftm1Sva/Braftm1Sva
Raf1tm2Bacc/Raf1+
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Sva mutation (1 available); any Braf mutation (62 available)
Raf1tm2Bacc mutation (2 available); any Raf1 mutation (116 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die before weaning

growth/size/body
• mice are smaller in the postnatal period than Braf conditional knockouts

nervous system
• deficiency of terminal axonal projections of parvalbumin-positive neurons toward the lateral motor pools of the spinal cord is seen compared to controls
• proprioceptive axons enter spinal cord normally, but few progress beyond intermediate zone
• at P12, number of Ret+ neurons in DRG is reduced; numbers of CGRG+ neurons are increased


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory