Phenotypes Associated with This Genotype

Genotype
MGI:3713552

• Allelic Composition: Braf^tm1Sva/Braf^tm1.1Sva; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:121660 )

• mice tend to die in third week postnatal, although some survive to P35

growth/size/body

decreased body weight ( J:121660 )

• at P32, body weight is ~25% of littermates

postnatal growth retardation ( J:121660 )

• from P12-14 onwards, mice show severe growth retardation

behavior/neurological

behavior/neurological phenotype ( J:121660 )

N • mice show normal nociceptive response in hotplate assay

hyperactivity ( J:121660 )

• mice appear hyperactive

nervous system

nervous system phenotype ( J:121660 )

N • dorsal root ganglion neurons survive in mutants

abnormal adenohypophysis morphology ( J:121660 )

• perivascular hypothalamic axonal innervation is reduced

small adenohypophysis ( J:121660 )

• anterior lobe of pituitary gland is markedly reduced in size compared to controls

thin cerebral cortex ( J:121660 )

• disproportionate thinning of cortex is observed

endocrine/exocrine glands

abnormal adenohypophysis morphology ( J:121660 )

• perivascular hypothalamic axonal innervation is reduced

small adenohypophysis ( J:121660 )

• anterior lobe of pituitary gland is markedly reduced in size compared to controls

homeostasis/metabolism

hypoglycemia ( J:121660 )

• mice display significantly reduced bolood glucose levels

abnormal body temperature homeostasis ( J:121660 )

• when separated from other mice, body temperature drops rapidly

abnormal growth hormone level ( J:121660 )

• level is elevated in pituitary relative to controls

• level of growth hormone is elevated in individual pituitary endocrine cells