Phenotypes Associated with This Genotype

Genotype
MGI:3713535

• Allelic Composition: Braf^tm1Wds/Braf^tm1.1Wds; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:121660 )

• mice tend to die in third week postnatal, although some survive to P35

growth/size/body

decreased body weight ( J:121660 )

• at P32, body weight is ~25% of littermates

postnatal growth retardation ( J:121660 )

• from P12-14 onwards, mice show severe growth retardation

endocrine/exocrine glands

abnormal adenohypophysis morphology ( J:121660 )

• perivascular hypothalamic axonal innervation to anterior lobe is reduced

small adenohypophysis ( J:121660 )

• anterior lobe of pituitary gland is markedly reduced in size compared to controls

behavior/neurological

behavior/neurological phenotype ( J:121660 )

N • mice show normal nociceptive response in hotplate assay

hyperactivity ( J:121660 )

• mice appear hyperactive

nervous system

nervous system phenotype ( J:121660 )

N • dorsal root ganglion neurons survive in mutants; lumbar-vertebral neuron counts at L4 and L5 are similar to wild-type

abnormal adenohypophysis morphology ( J:121660 )

• perivascular hypothalamic axonal innervation to anterior lobe is reduced

small adenohypophysis ( J:121660 )

• anterior lobe of pituitary gland is markedly reduced in size compared to controls

thin cerebral cortex ( J:121660 )

• disproportionate thinning of cortex is observed

homeostasis/metabolism

hypoglycemia ( J:121660 )

• mice display hypoglycemia with blood glucose levels ~70% below normal

abnormal body temperature homeostasis ( J:121660 )

• when separated from other mice, body temperature drops 5 degrees within 15 minutes

abnormal growth hormone level ( J:121660 )

• level is elevated in pituitary relative to controls

• level of growth hormone is elevated in individual pituitary endocrine cells