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Phenotypes Associated with This Genotype
Genotype
MGI:3713384
Allelic
Composition		 Chd4tm1.1Kge/Chd4tm1.2Kge
Tg(CAG-Bgeo/GFP)21Lbe/0
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd4tm1.1Kge mutation (0 available); any Chd4 mutation (58 available)
Chd4tm1.2Kge mutation (0 available); any Chd4 mutation (58 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:109547 )
• progressive decrease in cycling T cells is observed from second to third cell division in vitro, along with large number of nonblast T cells that appear to fail to enter cell cycle
decreased T cell proliferation ( J:109547 )
• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase

immune system
decreased T cell proliferation ( J:109547 )
• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase

hematopoietic system
decreased T cell proliferation ( J:109547 )
• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory