Phenotypes Associated with This Genotype

Genotype
MGI:3713383

• Allelic Composition: Chd4^tm1.1Kge/Chd4^tm1.1Kge; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased double-positive T cell number ( J:109547 )

• percentage of DP cells is reduced by 3-fold

arrested T cell differentiation ( J:109547 )

• differentiation of thymocytes stalls at the DN4 stage, but some do make the transition to DP eventually

• absolute number of double negative (DN) thymocytes is unaltered, or elevated despite decrease in thymus cellularity

increased CD8-positive, alpha-beta T cell number ( J:109547 )

• CD8 + T cells are increased to compensate for reduced DP cell numbers

abnormal CD4-positive, alpha beta T cell morphology ( J:109547 )

spleen hypoplasia ( J:109547 )

• 2- to 5-fold reduction in T cells in spleen is observed; decreased numbers of CD8+ and CD4+ populations is noted

abnormal T cell physiology ( J:109547 )

• DP and CD4+ T cells express lower levels of CD4, and CD8+ cells range from CD4^lo to CD4-

lymph node hypoplasia ( J:109547 )

• 2- to 5-fold reduction in T cells in lymph nodes is observed; decreased numbers of CD8+ and CD4+ populations is noted

hematopoietic system

decreased double-positive T cell number ( J:109547 )

• percentage of DP cells is reduced by 3-fold

arrested T cell differentiation ( J:109547 )

• differentiation of thymocytes stalls at the DN4 stage, but some do make the transition to DP eventually

• absolute number of double negative (DN) thymocytes is unaltered, or elevated despite decrease in thymus cellularity

increased CD8-positive, alpha-beta T cell number ( J:109547 )

• CD8 + T cells are increased to compensate for reduced DP cell numbers

abnormal CD4-positive, alpha beta T cell morphology ( J:109547 )

spleen hypoplasia ( J:109547 )

• 2- to 5-fold reduction in T cells in spleen is observed; decreased numbers of CD8+ and CD4+ populations is noted

abnormal T cell physiology ( J:109547 )

• DP and CD4+ T cells express lower levels of CD4, and CD8+ cells range from CD4^lo to CD4-