Phenotypes Associated with This Genotype

Genotype
MGI:3713333

• Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:104004 )

• present at expected numbers at E16.5

• 30% die in utero before birth when Cdkn1c^tm1Sje is maternally inherited

postnatal lethality, incomplete penetrance ( J:40203 )

• half expected numbers survive to 2 weeks of age

• Background Sensitivity: significant improvement in survival beyond day 1 of heterozygotes inheriting a maternal mutant when on an outbred CD1 background

endocrine/exocrine glands

enlarged adrenal glands ( J:40203 )

• significantly enlarged and displaying cytomegaly

cellular

paternal imprinting ( J:40203 )

• paternal allele is transcriptionally repressed

• no abnormal phenotype in crosses between heterozygous males and wild-type females