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Phenotypes Associated with This Genotype
Genotype
MGI:3713115
Allelic
Composition
Atg5tm1Myok/Atg5tm1Myok
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic
Background
involves: 129S/SvEv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Atg5tm1Myok mutation (3 available); any Atg5 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• cardiomyocyte fiber cross-sectional area is increased following tamoxifen treatment
• however, cardiomyocyte fibers are otherwise normal
• increase in the heart to body weight ratio following tamoxifen treatment
• following tamoxifen treatment
• following tamoxifen treatment
• calcium cycling is impaired following tamoxifen treatment
• decrease in the autophagy levels following tamoxifen treatment

respiratory system
• increase in the lung to body weight ratio following tamoxifen treatment

muscle
• cardiomyocyte fiber cross-sectional area is increased following tamoxifen treatment
• however, cardiomyocyte fibers are otherwise normal
• following tamoxifen treatment

growth/size/body
• increase in the heart to body weight ratio following tamoxifen treatment
• increase in the lung to body weight ratio following tamoxifen treatment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory