Phenotypes Associated with This Genotype

Genotype
MGI:3713115

• Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/?
• Genetic Background: involves: 129S/SvEv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:121778 )

• cardiomyocyte fiber cross-sectional area is increased following tamoxifen treatment

• however, cardiomyocyte fibers are otherwise normal

increased heart weight ( J:121778 )

• increase in the heart to body weight ratio following tamoxifen treatment

dilated heart left ventricle ( J:121778 )

• following tamoxifen treatment

abnormal cardiac muscle contractility ( J:121778 )

• following tamoxifen treatment

abnormal myocardial fiber physiology ( J:121778 )

• calcium cycling is impaired following tamoxifen treatment

• decrease in the autophagy levels following tamoxifen treatment

respiratory system

increased lung weight ( J:121778 )

• increase in the lung to body weight ratio following tamoxifen treatment

muscle

increased myocardial fiber size ( J:121778 )

• cardiomyocyte fiber cross-sectional area is increased following tamoxifen treatment

• however, cardiomyocyte fibers are otherwise normal

abnormal cardiac muscle contractility ( J:121778 )

• following tamoxifen treatment

abnormal myocardial fiber physiology ( J:121778 )

• calcium cycling is impaired following tamoxifen treatment

• decrease in the autophagy levels following tamoxifen treatment

growth/size/body

increased heart weight ( J:121778 )

• increase in the heart to body weight ratio following tamoxifen treatment

increased lung weight ( J:121778 )

• increase in the lung to body weight ratio following tamoxifen treatment