Phenotypes Associated with This Genotype

Genotype
MGI:3713112

• Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:121778 )

• mice die after thoracic transverse aortic constriction of heart failure

cardiovascular system

dilated heart left ventricle ( J:121778 )

• 1 week following thoracic transverse aortic constriction (TAC) or a 7 day treatment with isoproterenol left ventricular dilation is observed

abnormal cardiovascular system physiology ( J:121778 )

• thoracic transverse aortic constriction (TAC) and isoproterenol induce severe cardiac dysfunction

congestive heart failure ( J:121778 )

• 4 weeks following TAC

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:121778 )

• following a 7 day treatment with isoproterenol the left ventricle is dilated and mice exhibit severe cardiac dysfuction, unlike wild-type mice where the treatment has no significant effect