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Phenotypes Associated with This Genotype
Genotype
MGI:3712646
Allelic
Composition		 Ightm2Mnz/Ightm2Mnz
Lyntm1Sor/Lyntm1Sor
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Mnz mutation (1 available); any Igh mutation (41 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:75653 )
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
increased B cell proliferation ( J:75653 )
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system
abnormal B cell physiology ( J:75653 )
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
increased B cell proliferation ( J:75653 )
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular
increased B cell proliferation ( J:75653 )
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory