Phenotypes Associated with This Genotype

Genotype
MGI:3712645

• Allelic Composition: Igh^tm1Mnz/Igh^tm1Mnz; Lyn^tm1Sor/Lyn^tm1Sor
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell physiology ( J:75653 )

• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Igh^tm1Mnz mice

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system

abnormal B cell physiology ( J:75653 )

• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Igh^tm1Mnz mice

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization