Phenotypes for Braf Cdkn2a MGI:3712026 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Braf^tm1Mmcm/Braf⁺ Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Mmcm mutation (4 available); any Braf mutation (62 available)
Cdkn2a^tm4Rdp mutation (0 available); any Cdkn2a mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung tumor incidence ( J:121715 )

• Cre-treated mice show scattered papillary adenomas with evidence of subpleural nodules harboring cords of atypical cells trapped within regions of mesenchymal proliferation

• 2/4 mice display multiple lung tumors with a bronchioalveolar component

respiratory system

increased lung tumor incidence ( J:121715 )

• Cre-treated mice show scattered papillary adenomas with evidence of subpleural nodules harboring cords of atypical cells trapped within regions of mesenchymal proliferation

• 2/4 mice display multiple lung tumors with a bronchioalveolar component

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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