Phenotypes Associated with This Genotype

Genotype
MGI:3712022

• Allelic Composition: Braf^tm1Mmcm/Braf⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:121715 )

• 8 weeks after adenoCre treatment, lungs show rapid cancer progression with increased proliferation compared to Trp53-sufficient mice

• tumors show nodules composed of central papillary structures with solid peripheral areas

• all double mutants show increased proliferation, and cells show altered nuclear morphology, while Trp53 conditional single mutants have normal lung phenotypes

increased lung adenocarcinoma incidence ( J:121715 )

• 2/5 mice are found to have prominent adenocarcinomas, composed of glandular structures lined by atypical cells with enlarged nuclei, hyperchromasia, contour irregularities, and prominent nucleoli

• large areas of necrosis are present in adenocarcinomas, with evidence of lymphatic and vascular invasion

respiratory system

increased lung tumor incidence ( J:121715 )

• 8 weeks after adenoCre treatment, lungs show rapid cancer progression with increased proliferation compared to Trp53-sufficient mice

• tumors show nodules composed of central papillary structures with solid peripheral areas

• all double mutants show increased proliferation, and cells show altered nuclear morphology, while Trp53 conditional single mutants have normal lung phenotypes

increased lung adenocarcinoma incidence ( J:121715 )

• 2/5 mice are found to have prominent adenocarcinomas, composed of glandular structures lined by atypical cells with enlarged nuclei, hyperchromasia, contour irregularities, and prominent nucleoli

• large areas of necrosis are present in adenocarcinomas, with evidence of lymphatic and vascular invasion

abnormal lung morphology ( J:121715 )

• 8 weeks after Cre treatment, some small airways display papillary hyperplasia, not seen in Braf-conditional mice