Phenotypes Associated with This Genotype

Genotype
MGI:3711202

• Allelic Composition: Ptprr^tm1Wjh/Ptprr^tm1Wjh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:121302 )

• on accelerating rotarod, mutants fall from rod more frequently and at lower rod speeds compared to wild-type controls

• in single bar and parallel bar tests, traverse times are similar to controls, but mutants have increased number of slips and more fall off bars than control mice

decreased grip strength ( J:121302 )

• mutants lose grip in a rope grip test after 90 seconds (15 falls/27 trials) compared to wild-type controls which can retain grip for ~120 seconds (5 falls/27 trials)

abnormal gait ( J:121302 )

• compared to controls, mice exhibit a clear aberration in hindlimb gait, moving slightly asymmetrically as if limping; controls plant both feet at a regular and equal distance while walking through a narrow alley

nervous system

nervous system phenotype ( J:121302 )

N • brain morphology is not altered in mutants; Purkinje cell number and morphology is unaffected relative to controls; ERK1/2 phosphorylation is elevated in some brain regions in mutants