Ptprr^tm1Wjh
Targeted Allele Detail

Summary

• Symbol: Ptprr^tm1Wjh
• Name: protein tyrosine phosphatase receptor type R; targeted mutation 1, Wiljan J A J Hendriks
• MGI ID: MGI:3710117
• Synonyms: Ptprr^-
• Gene: Ptprr Location: Chr10:115854118-116110837 bp, + strand Genetic Position: Chr10, 64.01 cM, cytoband A2
• Alliance: Ptprr^tm1Wjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121302
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was replaced by a neomycin resistance cassette. With the gene having 3 transcription start sites, loss of exon 6 would shift the reading frame in any residual transcript. Northern blot, immunoprecipitation and immunoblot confirmed absence of all isoforms in mutants. (J:121302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprr Mutation: 40 strains or lines available

References

• Original: J:121302 Chirivi RG, et al., Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice. J Neurochem. 2007 May;101(3):829-40
• All: 2 reference(s)