Mouse Genome Informatics
ot
    Slc16a2tm1Dgen/Y
either: (involves: C57BL/6N) or (involves: NMRI)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• 34% reduction in serum T4 levels (J:120737)
• uptake of [125I]T3 in the brain is severely impaired (J:120737)
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively (J:120737)
• however, clearance from the blood and liver uptake is normal (J:120737)
• 203% increase in serum T3 levels (J:120737)

nervous system
N
• unlike in human patients no reduction in brain size or brain morphology was observed (J:120737)

Mouse Models of Human Disease
OMIM IDRef(s)
Allan-Herndon-Dudley Syndrome; AHDS 300523 J:120737