About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3710595
Allelic
Composition
Slc16a2tm1Dgen/Y
Genetic
Background
either: (involves: C57BL/6N) or (involves: NMRI)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc16a2tm1Dgen mutation (0 available); any Slc16a2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively
• however, clearance from the blood and liver uptake is normal
• 34% reduction in serum T4 levels
• uptake of [125I]T3 in the brain is severely impaired
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively
• however, clearance from the blood and liver uptake is normal
• 203% increase in serum T3 levels

nervous system
N
• unlike in human patients no reduction in brain size or brain morphology was observed

Mouse Models of Human Disease
OMIM ID Ref(s)
Allan-Herndon-Dudley Syndrome; AHDS 300523 J:120737


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory