Phenotypes for Cd19 Rbpj Spen MGI:3710554 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Rbpj^tm1Hon/Rbpj^tm1Hon Spen^tm2.1Hon/Spen^tm2.1Hon
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Rbpj^tm1Hon mutation (2 available); any Rbpj mutation (191 available)
Spen^tm2.1Hon mutation (3 available); any Spen mutation (137 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased marginal zone B cell number ( J:121523 )

• severely decreased numbers of marginal zone B cells in spleen

increased follicular B cell number ( J:121523 )

• increased numbers of follicular B cells in spleen

hematopoietic system

decreased marginal zone B cell number ( J:121523 )

• severely decreased numbers of marginal zone B cells in spleen

increased follicular B cell number ( J:121523 )

• increased numbers of follicular B cells in spleen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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