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Phenotypes Associated with This Genotype
Genotype
MGI:3710382
Allelic
Composition		 Tsg101tm1Kuw/Tsg101tm1Kuw
Tg(Wap-cre)11738Mam/0
Tg(Wap-Tsg101)4389Kuw/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Tg(Wap-Tsg101)4389Kuw mutation (1 available)
Tsg101tm1Kuw mutation (1 available); any Tsg101 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:121475 )
N
• Tsg101 transgene expression rescues mammary epithelial cells
• overexpression of Tsg101 supports expansion of secretory alveolar lobules relative to conditional Tsg101 knockouts, and tissue no longer shows mosaic pattern like non Tsg101-transgenics

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory