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Phenotypes Associated with This Genotype
Genotype
MGI:3710361
Allelic
Composition		 Smad5tm1Huy/Smad5tm1.1Huy
Tg(Tie1-cre)9Ref/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad5tm1.1Huy mutation (0 available); any Smad5 mutation (26 available)
Smad5tm1Huy mutation (0 available); any Smad5 mutation (26 available)
Tg(Tie1-cre)9Ref mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:121072 )
N
• mutants exhibit normal blood vessel development, normal blood vessel morphology in adults, normal angiogenesis, and a similar vascular remodeling response as controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory