Phenotypes Associated with This Genotype

Genotype
MGI:3710240

• Allelic Composition: Rb1^tm1Tyj/Rb1^tm2Brn; Rbl1^tm1Tyj/Rbl1⁺; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:120315 )

• mice have much more aggressive, invasive form of retinoblastoma than Trp53-sufficient compound mutants, but onset is delayed compared to that observed in Rbl1 homozygous compound mutants

• tumor size varies with age and genotype

• mice show rapid filling of the vitreal cavity with densely packed tumor cells and rosettes; in the tumors, there is an overabundance of stage II retinoblastoma cells

• near outer surface of retina near tumor origin site, there are regions of plexus with synaptic densities and synaptic vesicles, indistinguishable from the Rb1;Rbl1 mutants that are wild-type for Trp53

increased retinoblastoma incidence ( J:120315 )

• significant disruptions in retinal morphology are observed by P12 to 13

neoplasm

increased retinoblastoma incidence ( J:120315 )

• significant disruptions in retinal morphology are observed by P12 to 13