Phenotypes Associated with This Genotype

Genotype
MGI:3710214

• Allelic Composition: Sox9^tm1Gsr/Sox9^tm1Gsr; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121352 )

• die at birth

cardiovascular system

thick interventricular septum ( J:121352 )

• width of the interventricular septum is increased

abnormal heart valve morphology ( J:121352 )

• heart valve leaflets are thickened at E18.5

• abnormal organization of the stratified extracellular matrix layers within the valve leaflets

abnormal mitral valve morphology ( J:121352 )

abnormal tricuspid valve morphology ( J:121352 )

respiratory system

abnormal respiration ( J:121352 )

• respiratory defects