Phenotypes for Sox9 Tg(Col2a1-cre)1Bhr MGI:3710214 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sox9^tm1Gsr/Sox9^tm1Gsr Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9^tm1Gsr mutation (2 available); any Sox9 mutation (33 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121352 )

• die at birth

cardiovascular system

thick interventricular septum ( J:121352 )

• width of the interventricular septum is increased

abnormal heart valve morphology ( J:121352 )

• heart valve leaflets are thickened at E18.5

• abnormal organization of the stratified extracellular matrix layers within the valve leaflets

abnormal mitral valve morphology ( J:121352 )

abnormal tricuspid valve morphology ( J:121352 )

respiratory system

abnormal respiration ( J:121352 )

• respiratory defects

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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