Phenotypes Associated with This Genotype

Genotype
MGI:3710208

• Allelic Composition: Sox9^tm1Gsr/Sox9^tm1Gsr; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121352 )

• die between E11.5 and E14.5

cardiovascular system

conotruncal ridge hypoplasia ( J:121352 )

• endocardial cushions within the outflow tract appear grossly reduced in size

abnormal fetal atrioventricular canal morphology ( J:121352 )

• in the atrioventricular canal, there is malalignment of the atrial septum, although the septum does meet the endocardial cushions in more distal areas

abnormal atrioventricular cushion morphology ( J:121352 )

• endocardial cushions are hypoplastic and fail to elongate and form atrioventricular valve primordia at E13.5

• at E12.5, cell proliferation within the endocardial cushion is reduced by 75%

abnormal heart valve development ( J:121352 )

• defects in valve maturation

abnormal atrioventricular valve development ( J:121352 )

• atrioventricular valve primordia do not form at E13.5

abnormal interatrial septum morphology ( J:121352 )

• incomplete formation of the atrial septum

pericardial edema ( J:121352 )

abnormal blood circulation ( J:121352 )

• mutants exhibit increased blood pooling

homeostasis/metabolism

pericardial edema ( J:121352 )