About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3710184
Allelic
Composition		 Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129 * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (33 available)
Tg(IghMyc)22Bri mutation (2 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:120284 )
• the median lifespan of 31 days

neoplasm
increased tumor incidence ( J:120284 )
• based on median survival time, mice carrying single Trp53tm1Brd allele were no more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d+ allele

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory