Phenotypes for Cdkn2a Ppm1d Tg(IghMyc)22Bri MGI:3710182 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a⁺ Ppm1d^tm1Lad/Ppm1d^tm1Lad Tg(IghMyc)22Bri/0
Genetic Background	involves: 129 * C57BL * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Cjs mutation (5 available); any Cdkn2a mutation (59 available)
Ppm1d^tm1Lad mutation (1 available); any Ppm1d mutation (33 available)
Tg(IghMyc)22Bri mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120284 )

• the median lifespan of >130 days

neoplasm

decreased tumor incidence ( J:120284 )

• similar to mice carrying double Ppm1d^tm1Lad allele without Cdkn2a^tm1Cjs allele, based on increased median survival time, mice carrying single Cdkn2a^tm1Cjs allele were considerably more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d⁺ allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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