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Phenotypes Associated with This Genotype
Genotype
MGI:3710180
Allelic
Composition		 Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (33 available)
Tg(IghMyc)22Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:120284 )
• the median lifespan of 138 days

neoplasm
decreased tumor incidence ( J:120284 )
• mice carrying double Ppm1dtm1Lad allele were considerably more resistant to tumor formation induced by myc than wild-type transgenic litter mates based on increased median survival time by about 60 days

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory