Phenotypes Associated with This Genotype

Genotype
MGI:3708981

• Allelic Composition: Sphk1^tm1.1Cgh/Sphk1^tm2Cgh; Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus cell ratio ( J:120783 )

• accumulation of mature T cells in the thymus without changes in other thymic subsets

abnormal NK cell differentiation ( J:154069 )

• mice exhibit a reduction in NK cell egression from the peripheral lymph nodes compared with wild-type mice

abnormal T cell differentiation ( J:120783 )

• accumulation of mature T cells in the thymus without changes in other thymic subsets

decreased B cell number ( J:120783 )

• blood and lymph B cell counts are significantly lower than controls

• however, the number of B cells in the spleen and lymph node is normal

decreased NK cell number ( J:154069 )

• in the spleen and lymph

increased NK cell number ( J:154069 )

• in bone marrow and slightly in the lymph nodes

decreased T cell number ( J:120783 )

• mice treated with polyinosine polycytidylic acid at P3 - 5 display markedly reduced T cell number in blood and lymph

• however, spleen and lymph node T cell numbers are normal

abnormal immune serum protein physiology ( J:120783 )

• undetectable levels of sphingosine-1-phosphate (S1P) in the plasma and lymph

hematopoietic system

abnormal thymus cell ratio ( J:120783 )

• accumulation of mature T cells in the thymus without changes in other thymic subsets

abnormal NK cell differentiation ( J:154069 )

• mice exhibit a reduction in NK cell egression from the peripheral lymph nodes compared with wild-type mice

abnormal T cell differentiation ( J:120783 )

• accumulation of mature T cells in the thymus without changes in other thymic subsets

decreased bone marrow cell number ( J:120783 )

• decrease in the number of mature B cells in the bone marrow

• however, immature cell numbers are similar to controls

decreased B cell number ( J:120783 )

• blood and lymph B cell counts are significantly lower than controls

• however, the number of B cells in the spleen and lymph node is normal

decreased NK cell number ( J:154069 )

• in the spleen and lymph

increased NK cell number ( J:154069 )

• in bone marrow and slightly in the lymph nodes

decreased T cell number ( J:120783 )

• mice treated with polyinosine polycytidylic acid at P3 - 5 display markedly reduced T cell number in blood and lymph

• however, spleen and lymph node T cell numbers are normal

endocrine/exocrine glands

abnormal thymus cell ratio ( J:120783 )

• accumulation of mature T cells in the thymus without changes in other thymic subsets

cardiovascular system

hemorrhage ( J:205423 )

• after ovalbumin and CFA challenge, pIpC-treated mice exhibit bleeding in the draining peripheral lymph nodes and increased permeability to FITC-dextran unlike control mice

• however, pIpC-treated mice do not exhibit spontaneous bleeding into mucosal lymph nodes

increased vascular permeability ( J:205423 )

• after ovalbumin and CFA challenge, pIpC-treated mice exhibit bleeding in the draining peripheral lymph nodes and increased permeability to FITC-dextran unlike control mice

• however, pIpC-treated mice do not exhibit spontaneous bleeding into mucosal lymph nodes and transfusion with wild-type platelets reduces vascular leakage of FITC-dextran