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Phenotypes Associated with This Genotype
Genotype
MGI:3707974
Allelic
Composition		 Disc1Rgsc1390/Disc1Rgsc1393
Genetic
Background		 B6.Cg-Disc1Rgsc1390/Disc1Rgsc1393
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disc1Rgsc1390 mutation (2 available); any Disc1 mutation (69 available)
Disc1Rgsc1393 mutation (2 available); any Disc1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal prepulse inhibition ( J:120634 )
• compound heterozygotes for these two alleles exhibit greatly reduced prepulse inhibition (PPI; p<0.001), i.e., less reduction of the startle response following a prepulse, compared to wild-type mice

behavior/neurological
decreased startle reflex ( J:120634 )
• in the absence of a prepulse, the amplitude of the acoustic startle response of compound heterozygotes is significantly lower (p<0.05) than that of wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory