Phenotypes Associated with This Genotype

Genotype
MGI:3707499

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Rbl1^tm1Htr/Rbl1⁺; Tg(En2-cre)22Alj/0
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:83783 )

• mutants develop ataxia between P15 and P20

nervous system

increased neuron apoptosis ( J:83783 )

• increase in apoptotic rate is seen at P15 in vermis of mutants; most apoptotic cells are found in the inner half of the external granule layer and in the inner granule layer; rate is similar at P30

abnormal neuronal precursor proliferation ( J:83783 )

• at P15, number of proliferating granule cell precursors in external granule layer is higher than in controls

abnormal cerebellum vermis morphology ( J:83783 )

• at P15, the vermis is considerably reduced in size, but less than when both Rbl1 alleles are lost

cerebellum hypoplasia ( J:83783 )

• at P15, size reduction compared to wild-type cerebella is noticed

cellular

increased neuron apoptosis ( J:83783 )

• increase in apoptotic rate is seen at P15 in vermis of mutants; most apoptotic cells are found in the inner half of the external granule layer and in the inner granule layer; rate is similar at P30

abnormal neuronal precursor proliferation ( J:83783 )

• at P15, number of proliferating granule cell precursors in external granule layer is higher than in controls