Phenotypes Associated with This Genotype

Genotype
MGI:3707498

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Rbl1^tm1Htr/Rbl1^tm1Htr; Tg(En2-cre)22Alj/0
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:83783 )

• mutants develop ataxia between P15 and P20

nervous system

abnormal neuronal precursor proliferation ( J:83783 )

• increased proliferation is even more pronounced in cerebella of mutants at P15 and 20

abnormal cerebellar cortex morphology ( J:83783 )

• at P20, mice have highly disorganized cerebellar architecture in median cerebellar region

abnormal Purkinje cell morphology ( J:83783 )

• dendritic arborization appears shrunken, with stunted to misoriented dendrites

• cell bodies are poorly aligned with loss of laminar distribution

• occasionally bi-nucleated neurons are observed

thin cerebellar molecular layer ( J:83783 )

• layer is reduce in size

abnormal cerebellum vermis morphology ( J:83783 )

• at P15, the vermis is severely reduced in size

cellular

abnormal neuronal precursor proliferation ( J:83783 )

• increased proliferation is even more pronounced in cerebella of mutants at P15 and 20