Analysis Tools
immune system
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• mice infected with 500 CFU of S. aureus show half the number of granulocytes infiltrate the eyes compared to infected wild-type eyes at 24 hours after infection
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• continuous treatment with recombinant murine IL12 results in sustained recruitment of NK cells to the liver
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• osteoclasts are resistant to estrogen induced apoptosis
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• by 7 days after TMEV infection, inflammation is present in the meninges and gray matter, but decreases by 21 days, although not as much as in controls (B6)
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• by 7 days after TMEV infection, inflammation is present, decreasing slightly by 21 days, but widespread tissue damage is present, similar to controls (B6)
• tissue damage is less frequent at 45 days than in Prf-null mice
• at 180 days, some degree of brain pathology is still present, while inflammation is absent in controls
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• mice infected with 500 CFU of S. aureus show signs of severe intraocular inflammation and tissue destruction
• mice infected with 500 CFU of S. aureus show half the number of granulocytes infiltrate the eyes compared to infected wild-type eyes at 24 hours after infection
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• after BDL, necroinflammatory foci and lymphocytic infiltration are obviously less than in controls
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• mice infected with 500 CFU of S. aureus have drastically elevated number of S. aureus CFU compared to similarly-infected wild-type mice
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• inflammation and tissue damage in the brain are slightly greater than in control, resistant mice at 45 and 180 days
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reproductive system
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• sperm apoptosis is decreased compared to in wild-type mice
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• epididymal sperm count is increased compared to in wild-type mice due to decreased sperm apoptosis
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liver/biliary system
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• hepatocyte cell death is reduced compared to controls after BDL
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• after BDL, necroinflammatory foci and lymphocytic infiltration are obviously less than in controls
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• confluent foci of feathery hepatocyte degeneration due to bile acid cytotoxicity are significantly reduced compared to controls 24 hours after BDL
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• necroinflammatory foci after BDL are reduced in number compared to controls after BDL
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vision/eye
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• mice infected with 500 CFU of S. aureus show signs of severe intraocular inflammation and tissue destruction
• mice infected with 500 CFU of S. aureus show half the number of granulocytes infiltrate the eyes compared to infected wild-type eyes at 24 hours after infection
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• mice have only 7% of b-wave amplitude remaining at 24 hours after infection with 500CFU S. aureus, and show no detectable retinal function after this time point
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nervous system
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• by 7 days after TMEV infection, inflammation is present in the meninges and gray matter, but decreases by 21 days, although not as much as in controls (B6)
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• by 7 days after TMEV infection, inflammation is present, decreasing slightly by 21 days, but widespread tissue damage is present, similar to controls (B6)
• tissue damage is less frequent at 45 days than in Prf-null mice
• at 180 days, some degree of brain pathology is still present, while inflammation is absent in controls
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• at 45 days and later time points, there is minimal or no pathology, similar to controls and in contrast to Prf-null mice
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homeostasis/metabolism
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• one day following bile duct ligation (BDL), serum ALT levels are significantly lower than controls
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hematopoietic system
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• mice infected with 500 CFU of S. aureus show half the number of granulocytes infiltrate the eyes compared to infected wild-type eyes at 24 hours after infection
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• continuous treatment with recombinant murine IL12 results in sustained recruitment of NK cells to the liver
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• osteoclasts are resistant to estrogen induced apoptosis
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skeleton
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• osteoclasts are resistant to estrogen induced apoptosis
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cellular
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• sperm apoptosis is decreased compared to in wild-type mice
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• hepatocyte cell death is reduced compared to controls after BDL
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