Phenotypes Associated with This Genotype

Genotype
MGI:3707164

• Allelic Composition: Kitl^tm1Pbes/Kitl^tm1Pbes
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:50150 )

• at a sublethal dose of 6.5 Gy, mutants display only 50-60% survival rate after 4 weeks, while controls show 95-100% survival; mortality onset is invariably between 12 and 20 days

hematopoietic system

hematopoietic system phenotype ( J:50150 )

N • no significant differences are observed in hematopoietic parameters like erthroid volume, bone marrow cellularity, red and white blood cell numbers, platelet or neutrophil numbers, or lymphocyte subset numbers

decreased mast cell number ( J:50150 )

• mast cell numbers in skin and peritoneal tissue are decreased compared to wild-type; skin at 15 weeks contains only 8% of that in control tissue, and peritoneal mast cell numbers is <2% of that in controls

immune system

decreased mast cell number ( J:50150 )

• mast cell numbers in skin and peritoneal tissue are decreased compared to wild-type; skin at 15 weeks contains only 8% of that in control tissue, and peritoneal mast cell numbers is <2% of that in controls

homeostasis/metabolism

abnormal blood homeostasis ( J:50150 )

• after irradiation, increase in Kit ligand in serum of mutants (0.3 ng/ml to 0.7 ng/ml) is much less than in wild-type (0.3 ng/ml vs 2.2 ng/ml after irradiation)

increased mortality induced by ionizing radiation ( J:50150 )

• at a sublethal dose of 6.5 Gy, mutants display only 50-60% survival rate after 4 weeks, while controls show 95-100% survival; mortality onset is invariably between 12 and 20 days